In Isaiah, chapter one, verse three, “The ox knoweth his owner, and the ass his master’s crib: but Israel doth not know, my people doth not consider.” Here, “Israel” refers to all the twelve tribes, including Judah. The Twelve Tribes of Israel are described as the descendants of Jacob, a Hebrew patriarch who was the son of Isaac and, by extension, a grandson of Abraham. Jacob, later known as Israel, had twelve sons, from whom each tribe’s ancestry and namesake is derived: Reuben, Simeon, Levi, Judah, Dan, Naphtali, Gad, Asher, Issachar, Zebulun, Joseph, and Benjamin.
The theme verse depicts how the ox and the ass are selected as the least intelligent of domesticated animals. Yet, these animals know that relation, and act according to it; but Israel did not, or rather would not, know. That a man should be able to forget God and live as if there were no such Being is strange. The attitude is odd and unnatural. It is one instance of that awful power of ignoring the most important subjects, of which every life affords so many and tragic instances.
The attitude is fatal. It separates us from God, and separation from Him is the very definition of total eternal loss. A God of whom we never think is all the same to us as a God who does not exist. Strike God out of a life, and you strike the sun out of the system, and wrap all in darkness and chaos. ‘This is life eternal, to know Thee’; but if ‘Israel doth not know,’ Israel has hurt itself.
The situation here is like a child grown up in a godly home. However, they decide to try the wortld on their own. More like an experiment only to find out that there is a force.